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Tailoring the Electron–Phonon Interaction in Au25(SR)18 Nanoclusters via Ligand Engineering and Insight into Luminescence
Understanding the electron–phonon interaction in Au nanoclusters (NCs) is essential for enhancing and tuning their photoluminescence …
Zhongyu Liu, Yingwei Li, Ellen Kahng, Shan Xue, Xiangsha Du, Site Li, Rongchao Jin
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Self-sacrificial tyrosine cleavage by an Fe:Mn oxygenase for the biosynthesis of para-aminobenzoate in Chlamydia trachomatis
Chlamydia protein associating with death domains (CADD) is involved in the biosynthesis of para-aminobenzoate (pABA), an essential …
Olivia M Manley, Han N Phan, Allison K Stewart, Dontae A Mosley, Shan Xue, Lide Cha, Hongxia Bai, Veda C Lightfoot, Pierson A Rucker, Leonard Collins, Taufika Islam Williams, Wei-chen Chang, Yisong Guo, Thomas M Makris
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Mechanism of Methyldehydrofosmidomycin Maturation: Use Olefination to Enable Chain Elongation
Utilization of mononuclear iron- and 2-oxoglutarate-dependent (Fe/2OG) enzymes to enable C–H bond functionalization is a widely used …
Xiaojun Li, Shan Xue, Yisong Guo, Wei-chen Chang
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Mechanism of Methyldehydrofosmidomycin Maturation: Use Olefination to Enable Chain Elongation
BesC Initiates C–C Cleavage through a Substrate-Triggered and Reactive Diferric-Peroxo Intermediate
BesC catalyzes the iron- and O2-dependent cleavage of 4-chloro-l-lysine to form 4-chloro-l-allylglycine, formaldehyde, and ammonia. …
Olivia M Manley, Haoyu Tang, Shan Xue, Yisong Guo, Wei-chen Chang, Thomas M Makris
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BesC Initiates C–C Cleavage through a Substrate-Triggered and Reactive Diferric-Peroxo Intermediate
Deciphering pyrrolidine and olefin formation mechanism in kainic acid biosynthesis
metalloenzyme, C−H activation, cyclization, desaturation, enzyme mechanism
Tzu-Yu Chen, Shan Xue, Wei-Chih Tsai, Tun-Cheng Chien, Yisong Guo, Wei-chen Chang
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Deciphering pyrrolidine and olefin formation mechanism in kainic acid biosynthesis
Alternative Reactivity of Leucine 5-Hydroxylase Using an Olefin-Containing Substrate to Construct a Substituted Piperidine Ring
Applying enzymatic reactions to produce useful molecules is a central focus of chemical biology. Iron and 2-oxoglutarate (Fe/2OG) …
Lide Cha, Sergey Milikisiyants, Madison Davidson, Shan Xue, Tatyana Smirnova, Alex Smirnov, Yisong Guo, Wei-chen Chang
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Alternative Reactivity of Leucine 5-Hydroxylase Using an Olefin-Containing Substrate to Construct a Substituted Piperidine Ring